HORDB

ID: hor001892
Uniprot ID: P0DJ95
Protein name: Pituitary adenylate cyclase-activating polypeptide 38
Gene name: Adcyap1
Organism: Heloderma suspectum (Gila monster)
Family: Glucagon family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Heloderma (genus), Helodermatidae (family), Neoanguimorpha, Anguimorpha (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
GO BP: GO:0007165 signal transduction; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0010628 positive regulation of gene expression; GO:0030073 insulin secretion; GO:0060124 positive regulation of growth hormone secretion
GO CC: GO:0005576 extracellular region

Function: Promotes neuron projection development
Mechanism: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cell
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001892_AF2.pdb

hor001892_ESM.pdb

Mass:	448048	Formula:	C176H279N51O48S
Absent amino acids:	CENPW	Common amino acids:	K
pI:	10.6	Basic residues:	9
Polar residues:	10	Hydrophobic residues:	9
Hydrophobicity:	-86.97	Boman Index:	-8354
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	62.12
Instability Index:	3362.73	Extinction Coefficient cystines:	5960
Absorbance 280nm:	186.25